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KMID : 0363620230440040026
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Journal of Korean Oriental Medicine
2023 Volume.44 No. 4 p.26 ~ p.40
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Bojungikgi-tang for Anorexia in Lung Cancer Patients with Treated with Chemotherapy: A Single-arm, Open-label, Single-center Trial
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Cho Im-Hak
Yoon Seong-Hoon
Kim So-Yeon
Kang Byoung-Kab
Seo Chang-Seob
Choi Young-Eun
Shin Hyeun-Kyoo
Choi Jun-Yong
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Abstract
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Objectives: This study was to evaluate the effectiveness and safety of Bojungikgi-tang for lung cancer patients with anorexia.
Methods: This was a single-arm, open-label, and single-center trial, and suitable participants took Bojungikgi-tang (Buzhongyiqi-tang in Chinese, Hochuekki-to in Japanese) three times a day before or between meals for six weeks (42 days). After registration of clinical trials (visit 2), they visited the hospital every three weeks (visits 3 and 4) and measured or tested the effectiveness or safety evaluation variables to analyze the results. The primary outcome was the anorexia/cachexia subscale (A/CS) of functional assessment of anorexia/cachexia therapy (FAACT) score.
Results: Seventeen lung cancer patients were included in the intention-to-treat (ITT) analysis. Lung cancer patients had higher A/CS of FAACT scores after six weeks of Bojungikgi-tang administration compared to that at the baseline. This was not significant four lung cancer (p=0.1668). In the secondary outcomes, the visual analog scale (VAS) score of anorexia decreased significantly (p=0.0009), and the CD4/CD8 ratio (p=0.0396) and CD4 levels (p=0.0345) significantly increased after six weeks of treatment.
No serious adverse events were reported with Bojungikgi-tang in lung cancer patients.
Conclusions: Bojungikgi-tang can be an effective and safe treatment for anorexia in lung cancer patients undergoing chemotherapy.
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KEYWORD
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Anorexia, Bojungikgi-tang, Clinical Trial, Lung Neoplasm
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